redbird: closeup of me drinking tea, in a friend's kitchen (Default)
( Apr. 6th, 2022 02:46 pm)
I got a call from my neurologist's office this morning, following up on my question from a couple of weeks ago: they said the monoclonal antibodies took a week or two to reach maximum effectiveness, and were good for three to six months.

The first half of that answer would have been more useful two weeks ago, of course. For planning purposes, the relevant part now is that three to six months from when I got the antibodies puts me somewhere between the middle of June and the middle of September, and I guess we can see about getting me another dose in September.
With my new monoclonal anti-covid antibodies, I went for a walk unmasked, with a mask in my pocket in case I wanted to go into a building or otherwise needed it. It was sunny and unseasonably warm this afternoon, and I also did a bit of exercise on the back stairs.

I called the hair salon I last visited in February 2020, to ask if I could get my hair cut while wearing a face mask. The receptionist said yes, "whatever you're comfortable with." I also asked if, after two years, I should book a new client appointment. She checked with Taylor, the stylist who cut my hair in the past, and came back to say I didn't count as a new client, but should make a longer appointment; I will be getting my hair cut on March 30th.

After that phone call, I went to the Bona Fide Masks website, and ordered some Powecom KN95 masks with ear loops, because behind-the-head straps would interfere with a haircut. My plan is to wear an N95 or KN95 mask with behind-the-head straps on my way to the hair salon, and swap for the one with ear loops when I get there. (If these masks don't arrive in time, I will switch to a medical mask to get my hair cut.)

I also decided I was comfortable with [personal profile] cattitude going to the grocery store this afternoon, properly masked, so he could select his own produce. I suspect there's going to be some back-and-forth of what I, and cattitude and [personal profile] adrian_turtle, are comfortable with, a combination of having some time to think about it, warmer weather, any changes in the local case rate, and at some point declining protection from those store-bought antibodies.
Poking around a little, I found that (a) Evusheld is supposed to provide at least six months of protection, but (b) it may be less effective against omicron than against earlier variants, so (c) the FDA doubled the dosage last month, from 150 mg each of the two antibodies, to 300 mg each.

This is for pre-exposure prophylaxis, or PrEP, an acronym that some articles are assuming (correctly, in my case) that the reader knows.

The protection is at its strongest right now, and will diminish over time because the number of antibodies in the patient's system diminishes.

Putting this here largely for my own reference.

ETA 3/18: I found the AstraZeneca factsheet on Evusheld for medical providers, which includes the pharmacology: half-life is a mean 87.9 days (SD 13), which makes six months of protection seem plausible. (The person I talked to yesterday was guessing that the half-life would be about four weeks, based on the half-life of IgG treatments for hepatitis B.

[apparently it's "Evusheld," no i.}
I have had the Evushield monoclonal antibodies, for (some amount of) protection against covid. The factsheet didn't answer my questions -- how soon will I be protected, and for how long -- and the nurse said to ask my doctor. I left a message with his office, and also mentioned those questions on a discord server.

A medical person who hangs out there said that the time to them being effective should be "quick, on the order of hours" and that the answer to the other question is more complicated. Half-life in the bloodstream is probably about for weeks, but to actually answer that question, even approximately,a person would need to know how many antibodies they injected and how many are needed to be significantly protective.
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redbird: closeup of me drinking tea, in a friend's kitchen (Default)
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